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Target
B-cell lymphoma 6 protein [5-129]
Ligand
BDBM522261
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
102±n/a nM
Citation
 Bellenie, BR; Cheung, KM; Davis, OA; Hoelder, S; Huckvale, R; Lloyd, MG 2-quinolone derived inhibitors of BCL6 US Patent  US11161839 Publication Date 11/2/2021 
Target
Name:
B-cell lymphoma 6 protein [5-129]
Synonyms:
BCL5 | BCL6 | BCL6_HUMAN | BTB domain-containing protein 27 (BCL-6)(5-129) | LAZ3 | ZBTB27 | ZNF51
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14310.07
Organism:
Homo sapiens (Human)
Description:
aa 5-129
Residue:
125
Sequence:
ADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASE
  
Inhibitor
Name:
BDBM522261
Synonyms:
US11161839, Example 8f
Type:
Small organic molecule
Emp. Form.:
C30H26ClF3N8O2
Mol. Mass.:
623.028
SMILES:
CC(Nc1cc(=O)n(C)c2ccc(Nc3cc(nc(Cl)c3C#N)C(=O)N3CC(C3)C(F)(F)F)cc12)c1ncc(cn1)C1CC1
Structure:
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