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Target
B-cell lymphoma 6 protein [5-129]
Ligand
BDBM522322
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
47.9±n/a nM
Citation
 Bellenie, BR; Cheung, KM; Davis, OA; Hoelder, S; Huckvale, R; Lloyd, MG 2-quinolone derived inhibitors of BCL6 US Patent  US11161839 Publication Date 11/2/2021 
Target
Name:
B-cell lymphoma 6 protein [5-129]
Synonyms:
BCL5 | BCL6 | BCL6_HUMAN | BTB domain-containing protein 27 (BCL-6)(5-129) | LAZ3 | ZBTB27 | ZNF51
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14310.07
Organism:
Homo sapiens (Human)
Description:
aa 5-129
Residue:
125
Sequence:
ADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASE
  
Inhibitor
Name:
BDBM522322
Synonyms:
US11161839, Example 12i
Type:
Small organic molecule
Emp. Form.:
C26H28ClF2N9O2
Mol. Mass.:
572.009
SMILES:
Cn1c2ccc(Nc3nc(ncc3Cl)N3CCC(F)(F)C(CO)C3)cc2c(NC(C)(C)c2ncccn2)nc1=O
Structure:
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