Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [695-745,751-1022,T790M,C797S]
Ligand
BDBM50505839
Substrate
n/a
Meas. Tech.
Biochemical EGFR Inhibition Assays (100 mM ATP)
IC50
71.7±n/a nM
Citation
 Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent  US11174245 Publication Date 11/16/2021 
Target
Name:
Epidermal growth factor receptor [695-745,751-1022,T790M,C797S]
Synonyms:
EGFR | EGFR (aa 895-745, aa 751-1022, T790M, C797S) | EGFR_HUMAN | ERBB | ERBB1 | HER1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36756.18
Organism:
Human
Description:
P00533[695-745,751-1022,T790M,C797S]
Residue:
323
Sequence:
SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
  
Inhibitor
Name:
BDBM50505839
Synonyms:
CHEMBL4525935 | US11174245, # I-001
Type:
Small organic molecule
Emp. Form.:
C21H22N6O2
Mol. Mass.:
390.4384
SMILES:
Cn1cc(cn1)-c1cc(ccn1)C(=O)\N=c1/[nH]c2ccccc2n1CC(C)(C)O
Structure:
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