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Target
Epidermal growth factor receptor [695-745,751-1022,T790M,C797S]
Ligand
BDBM525457
Substrate
n/a
Meas. Tech.
Biochemical EGFR Inhibition Assays (100 mM ATP)
IC50
6.60±n/a nM
Citation
 Boese, D; Dahmann, G; Engelhardt, H; Petronczki, M; Scharn, D Benzimidazole compounds and derivatives as EGFR inhibitors US Patent  US11174245 Publication Date 11/16/2021 
Target
Name:
Epidermal growth factor receptor [695-745,751-1022,T790M,C797S]
Synonyms:
EGFR | EGFR (aa 895-745, aa 751-1022, T790M, C797S) | EGFR_HUMAN | ERBB | ERBB1 | HER1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36756.18
Organism:
Homo sapiens (Human)
Description:
P00533[695-745,751-1022,T790M,C797S]
Residue:
323
Sequence:
SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
  
Inhibitor
Name:
BDBM525457
Synonyms:
US11174245, # I-052
Type:
Small organic molecule
Emp. Form.:
C27H29N5O3
Mol. Mass.:
471.5509
SMILES:
CC(C)(O)Cn1c2ccc(cc2[nH]\c1=N/C(=O)c1ccnc(c1)-c1cccnc1)C1CCCOC1
Structure:
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