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Target
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Ligand
BDBM533750
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<25.0±n/a nM
Citation
 Zhang, H; Liu, S Heterocycles useful as anti-cancer agents US Patent  US11225492 Publication Date 1/18/2022 
Target
Name:
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Synonyms:
CDK2/Cyclin A2 | Cyclin-Dependent Kinase 2 (CDK2)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
Cyclin-A2 [177-432]
Synonyms:
CCN1 | CCNA | CCNA2 | CCNA2_HUMAN | Cyclin A2 | Cyclin-A
Type:
Subunit of Enzyme Complex
Mol. Mass.:
29394.24
Organism:
Human
Description:
P20248[177-432]
Residue:
256
Sequence:
DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
  
Inhibitor
Name:
BDBM533750
Synonyms:
Preparation of 5-(4-(6-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazin-1-yl)-N-hydroxy-5-oxopentanamide | US11225492, Compound 13
Type:
Small organic molecule
Emp. Form.:
C29H36N8O5
Mol. Mass.:
576.6467
SMILES:
CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)CCCC(=O)NO)nc2n(C2CCCC2)c1=O
Structure:
Search PDB for entries with ligand similarity: