Reaction Details Report a problem with these data
Target
Androgen receptor [633-919]
Ligand
BDBM468363
Substrate
n/a
Meas. Tech.
Affinity Assay
Ki
601±n/a nM
Citation
 Narayanan, R; Miller, DD; Ponnusamy, T; Hwang, D; He, Y Selective androgen receptor degrader (SARD) ligands and methods of use thereof US Patent  US11230523 Publication Date 1/25/2022 
Target
Name:
Androgen receptor [633-919]
Synonyms:
ANDR_HUMAN | AR | Androgen receptor (633-919) | DHTR | NR3C4
Type:
aa 633-919
Mol. Mass.:
33165.80
Organism:
Human
Description:
P10275[633-919]
Residue:
287
Sequence:
KKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
  
Inhibitor
Name:
BDBM468363
Synonyms:
US10806720, Compound 1059 | US11230523, Compound 1059 | US11648234, Compound 1059
Type:
Small organic molecule
Emp. Form.:
C21H15F5N4O2
Mol. Mass.:
450.3614
SMILES:
C[C@](O)(Cn1cc(c(F)n1)-c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F |r|
Structure:
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