Reaction Details Report a problem with these data
Target
Uromodulin
Ligand
BDBM50538420
Substrate
n/a
Meas. Tech.
In-Vitro Assay
IC50
43.0±n/a nM
Citation
 Sharma, R; Iyer, P; Agarwal, S Substituted sulfoximine compounds US Patent  US11236045 Publication Date 2/1/2022 
Target
Name:
Uromodulin
Synonyms:
THP | Tamm-Horsfall urinary glycoprotein | UMOD | UROM_HUMAN
Type:
Protein
Mol. Mass.:
69744.65
Organism:
Human
Description:
P07911
Residue:
640
Sequence:
MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRFVGQGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
  
Inhibitor
Name:
BDBM50538420
Synonyms:
CHEMBL4636825 | US11236045, Example 56
Type:
Small organic molecule
Emp. Form.:
C19H19N5O2S
Mol. Mass.:
381.451
SMILES:
O=C(Nc1c2CCCc2cc2CCCc12)NS(=O)(=NC#N)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: