Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM543116
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
IC50
0.300±n/a nM
Citation
 Bair, KW; Baumeister, TR; Buckmelter, AJ; Clodfelter, KH; Han, B; Lin, J; Reynolds, DJ; Smith, CC; Wang, Z; Zheng, X; Yuen, P Compounds and compositions for the inhibition of NAMPT US Patent  US11279687 Publication Date 3/22/2022 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Human
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM543116
Synonyms:
3-{4-[(2-chloro-5- methylphenyl)sulfamoyl]phenyl}-1-(pyridin- 3-ylmethyl)urea | US11279687, Compound 125
Type:
Small organic molecule
Emp. Form.:
C20H19ClN4O3S
Mol. Mass.:
430.908
SMILES:
Cc1ccc(Cl)c(NS(=O)(=O)c2ccc(NC(=O)NCc3cccnc3)cc2)c1
Structure:
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