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Target
Platelet-activating factor receptor
Ligand
BDBM552620
Substrate
n/a
Meas. Tech.
EVALUATION OF THE INHIBITION OF PAFR ACTIVATION
IC50
3.00±n/a nM
Citation
 Matthias, E; Kristina, WM; Juergen, P; Ferenc, K; Leo, T; Siegfried, TC; Dieter, W CYCLOPENTATHIOPHENE CARBOXAMIDE DERIVATIVES AS PLATELET ACTIVATING FACTOR RECEPTOR ANTAGONISTS WIPO WO2022101377 Publication Date -1/19/2022 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Human
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM552620
Synonyms:
WO2022101377, Example 19
Type:
Small organic molecule
Emp. Form.:
C22H24ClN5OS
Mol. Mass.:
441.977
SMILES:
CCCNC(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
Structure:
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