Target
Platelet-activating factor receptor
Ligand
BDBM552651
Substrate
n/a
Meas. Tech.
EVALUATION OF THE INHIBITION OF PAFR ACTIVATION
IC50
0.50±n/a nM
Citation
 Matthias, EKristina, WMJuergen, PFerenc, KLeo, TSiegfried, TCDieter, W CYCLOPENTATHIOPHENE CARBOXAMIDE DERIVATIVES AS PLATELET ACTIVATING FACTOR RECEPTOR ANTAGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM552651
Synonyms:
WO2022101377, Example 50
Type:
Small organic molecule
Emp. Form.:
C26H28ClN5OS
Mol. Mass.:
494.051
SMILES:
CCC12CC(C1)(C2)NC(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1
Structure:
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