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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM552693
Substrate
n/a
Meas. Tech.
VHL HEK-293 BRET Assay
IC50
120±n/a nM
Citation
 Jakob, F; Hao, W; J., FW 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXY-N-(BENZYL)PYRROLIDIN E-2-CARBOXAMIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA AND CANCER WIPO 0:0 (2022) [PubMed] 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM552693
Synonyms:
(2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-oxopropan-2-yl)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropyl-lH-l,2,3-triazol-l-yl)acetyl)-4-hydroxypyrrolidine-2-carboxamide (Compound 8) | WO2022103411, Example S8
Type:
Small organic molecule
Emp. Form.:
C37H44N6O4
Mol. Mass.:
636.7831
SMILES:
NC(=O)[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)[C@H](C1C2CC3CC(C2)CC1C3)n1cc(nn1)C1CC1 |wU:3.18,22.24,wD:28.44,TLB:28:29:31:33.34.35,THB:33:32:29:34.35.36,33:34:29:31.32.38,36:34:31:29.37.38,36:37:31:33.34.35,(-6.74,-5.5,;-8.1,-4.77,;-9.41,-5.57,;-8.14,-3.23,;-9.5,-2.5,;-10.81,-3.3,;-10.76,-4.84,;-12.07,-5.65,;-13.43,-4.92,;-13.47,-3.38,;-12.16,-2.57,;-14.74,-5.73,;-14.69,-7.27,;-16.01,-8.08,;-17.36,-7.34,;-17.4,-5.81,;-16.09,-5,;-6.83,-2.42,;-5.47,-3.15,;-5.43,-4.69,;-4.16,-2.34,;-4.05,-.81,;-2.55,-.44,;-1.96,.98,;-1.74,-1.75,;-2.74,-2.93,;-2.37,-4.42,;-3.49,-5.49,;-.9,-4.86,;.22,-3.79,;1.59,-3.1,;2.96,-3.79,;3.8,-2.32,;3.8,-.92,;2.43,-.23,;1.59,-1.7,;1.06,-.92,;1.06,-2.32,;2.43,-3.02,;-.53,-6.35,;.89,-6.94,;.77,-8.47,;-.72,-8.84,;-1.53,-7.53,;1.95,-9.47,;3.46,-9.75,;2.47,-10.92,)|
Structure:
Search PDB for entries with ligand similarity: