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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM552728
Substrate
n/a
Meas. Tech.
VHL HEK-293 BRET Assay
IC50
30±n/a nM
Citation
 Jakob, F; Hao, W; J., FW 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXY-N-(BENZYL)PYRROLIDIN E-2-CARBOXAMIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA AND CANCER WIPO 0:0 (2022) [PubMed] 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM552728
Synonyms:
(2S, 4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l-yl)-3,3-dimethylbutanoyl)-N-((2'-fluoro-[l,l'-biphenyl]-4-yl)methyl)-4-hydroxypyrrolidine-2-carboxamide (Compound 49) | WO2022103411, Compound 49 | WO2022103411, Example S43
Type:
Small organic molecule
Emp. Form.:
C29H34FN5O3
Mol. Mass.:
519.6104
SMILES:
CC(C)(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1ccccc1F)n1cc(nn1)C1CC1 |r|
Structure:
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