Reaction Details Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM560656
Substrate
n/a
Meas. Tech.
Evaluation of Aurora a and Aurora B Inhibitory Effect Kinase Assay
IC50
1314±n/a nM
Citation
 Cheng, D; Chen, M; Li, A; Li, H; Yang, G Heterocyclic compounds useful as aurora a selective inhibitors US Patent  US11384066 Publication Date 7/12/2022 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM560656
Synonyms:
4-((4-acetyl-3-fluoro-6-((5- methyl-1H-pyrazol-3-yl)- amino)pyridin-2-yl)methyl)-1- (3-chloro-2-fluorobenzyl)- piperidine-4-carboxylic acid | US11384066, Example 69
Type:
Small organic molecule
Emp. Form.:
C25H26ClF2N5O3
Mol. Mass.:
517.955
SMILES:
CC(=O)c1cc(Nc2cc(C)[nH]n2)nc(CC2(CCN(Cc3cccc(Cl)c3F)CC2)C(O)=O)c1F
Structure:
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