Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM571845
Substrate
n/a
Meas. Tech.
Binding Inhibition for Dopamine D3 Receptor
Ki
0.120±n/a nM
Citation
 Ichihashi, Y; Inagaki, M; Masuda, K Cyclic compound having dopamine D3 receptor antagonistic effect US Patent  US11447484 Publication Date 9/20/2022 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3 | DRD3_HUMAN | Dopamine D3 receptor
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Homo sapiens
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM571845
Synonyms:
US11447484, Compound I-002
Type:
Small organic molecule
Emp. Form.:
C32H36N4O2
Mol. Mass.:
508.6538
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCC(CC2)c2nocc2-c2ccccc2)CC1)c1cccc2ncccc12 |r,wU:3.2,wD:6.6,(5.76,-.16,;5.76,-1.7,;4.42,-2.47,;3.09,-1.7,;1.76,-2.47,;.42,-1.7,;.42,-.16,;-.91,.61,;-2.25,-.16,;-3.58,.61,;-4.91,-.16,;-6.25,.61,;-6.25,2.15,;-4.91,2.92,;-3.58,2.15,;-7.58,2.92,;-7.74,4.46,;-9.25,4.78,;-10.02,3.44,;-8.99,2.3,;-9.31,.79,;-10.77,.32,;-11.09,-1.19,;-9.95,-2.22,;-8.48,-1.75,;-8.16,-.24,;1.76,.61,;3.09,-.16,;7.09,-2.47,;7.09,-4.01,;8.42,-4.78,;9.76,-4.01,;9.76,-2.47,;11.09,-1.7,;11.09,-.16,;9.76,.61,;8.42,-.16,;8.42,-1.7,)|
Structure:
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