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Target
Transcriptional enhancer factor TEF-1
Ligand
BDBM574507
Substrate
n/a
Meas. Tech.
TEAD Inhibition Assay
EC50
300±n/a nM
Citation
 Castro, AC TEAD inhibitors and uses thereof US Patent  US11458149 Publication Date 10/4/2022 
Target
Name:
Transcriptional enhancer factor TEF-1
Synonyms:
NTEF-1 | Protein GT-IIC | TCF-13 | TCF13 | TEA domain family member 1 | TEAD-1 | TEAD1 | TEAD1_HUMAN | TEF1 | Transcription factor 13 | Transcriptional enhancer factor TEF-1
Type:
PROTEIN
Mol. Mass.:
47954.57
Organism:
Homo sapiens
Description:
ChEMBL_109666
Residue:
426
Sequence:
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
  
Inhibitor
Name:
BDBM574507
Synonyms:
US11458149, Compound I-60
Type:
Small organic molecule
Emp. Form.:
C20H19F3N2O
Mol. Mass.:
360.3729
SMILES:
FC(F)(F)c1cccc(CN2C[C@H](Cc3ccccc23)NC(=O)C=C)c1 |r|
Structure:
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