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Target
Prostaglandin G/H synthase 2
Ligand
BDBM578156
Substrate
n/a
Meas. Tech.
Enzyme (COXs) Inhibition Assay
IC50
68.0±8 nM
Citation
 Elsayed, MK; Burayk, S Method for treating inflammation US Patent  US11478464 Publication Date 10/25/2022 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase-2 (COX-2) | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (PGHS-2)(FLAG-Native)
Type:
Enzyme
Mol. Mass.:
69995.82
Organism:
Homo sapiens (Human)
Description:
P35354; containing a FLAG tag at the N terminus
Residue:
612
Sequence:
DYKDDDDKMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM578156
Synonyms:
US11478464, Compound 1 | benzimidazol-2-yl)piperidin-1-
Type:
Small organic molecule
Emp. Form.:
C22H24N4O3
Mol. Mass.:
392.451
SMILES:
Cc1cccc2[nH]c(nc12)C1CCCN(C1)C(=O)c1ccccc1NCC(O)=O
Structure:
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