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Target
RAC-alpha serine/threonine-protein kinase [1-472,474-480]
Ligand
BDBM580875
Substrate
n/a
Meas. Tech.
pAKT Protocol
IC50
1000±n/a nM
Citation
 Stocking, EM; Wrasidlo, WJ Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways US Patent  US11492348 Publication Date 11/8/2022 
Target
Name:
RAC-alpha serine/threonine-protein kinase [1-472,474-480]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | pAKT
Type:
Enzyme
Mol. Mass.:
55594.17
Organism:
Homo sapiens (Human)
Description:
P31749[1-472,474-480]
Residue:
479
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFYSASGTA
  
Inhibitor
Name:
BDBM580875
Synonyms:
5-(3-((difluoro(phenyl)methyl)sulfonyl)-5- morpholinophenyl)pyrimidin-2-amine | US11492348, Compound 87
Type:
Small organic molecule
Emp. Form.:
C21H20F2N4O3S
Mol. Mass.:
446.47
SMILES:
Nc1ncc(cn1)-c1cc(cc(c1)S(=O)(=O)C(F)(F)c1ccccc1)N1CCOCC1
Structure:
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