Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM250626
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
410±n/a nM
Citation
 Carroll, C; Goldby, A; Teall, M Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases US Patent  US11512066 Publication Date 11/29/2022 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Human
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM250626
Synonyms:
US10167273, Example 107 | US10544126, Example 107 | US11512066, Example 107 | US9475795, 105 | US9475795, 106 | US9475795, 107
Type:
Small organic molecule
Emp. Form.:
C17H21ClFN3O2S
Mol. Mass.:
385.884
SMILES:
Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: