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Target
Dihydrofolate reductase
Ligand
BDBM50531799
Substrate
n/a
Meas. Tech.
TBD
IC50
1622±n/a nM
Citation
 Thomas, SB; Hopper, AT; Welsch, M Compositions and methods for treating infections US Patent  US11530198 Publication Date 12/20/2022 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50531799
Synonyms:
CHEMBL4435247 | US11530198, Example 66
Type:
Small organic molecule
Emp. Form.:
C17H22N6
Mol. Mass.:
310.3968
SMILES:
Nc1ncc(N2CCN(CC2)c2cccc(c2)C2CC2)c(N)n1
Structure:
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