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Target
Diacylglycerol kinase alpha [9-727]
Ligand
BDBM594506
Substrate
n/a
Meas. Tech.
In Vitro DGK Inhibition Assay
IC50
25.0±n/a nM
Citation
 Velaparthi, U; Olson, RE; Darne, CP; Dasgupta, B; Warrier, JS; Rahaman, H; Jalagam, PR; Roy, S; Grunenfelder, DC Substituted pyridopyrimidinonyl compounds useful as T cell activators US Patent  US11584747 Publication Date 2/21/2023 
Target
Name:
Diacylglycerol kinase alpha [9-727]
Synonyms:
DAGK | DAGK1 | DGKA | DGKA_HUMAN
Type:
PROTEIN
Mol. Mass.:
80817.73
Organism:
Human
Description:
P23743 [9-727]
Residue:
719
Sequence:
SPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRS
  
Inhibitor
Name:
BDBM594506
Synonyms:
US11584747, Example 313 | US11584747, Example 314
Type:
Small organic molecule
Emp. Form.:
C27H34N6O2
Mol. Mass.:
474.5979
SMILES:
CC[C@@H]1CN([C@@H](C)CN1C(C(C)C)c1ccc(OC)cc1)c1nc(=O)n(C)c2ccc(nc12)C#N |r|
Structure:
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