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Target
Nucleoprotein
Ligand
BDBM601586
Substrate
n/a
Meas. Tech.
Plaque Reduction Assay
EC50
28.0±n/a nM
Citation
 Cockerill, GS; Good, J; Cochrane, EJ Pharmaceutical compounds US Patent  US11634425 Publication Date 4/25/2023 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM601586
Synonyms:
N-[(3S)-9-fluoro- 2-oxo-5-phenyl- 1,3-dihydro-1,4- benzodiazepin-3- yl]-2-(3- fluoropyridin-4- yl)-6-methoxy- imidazo[1,2- b]pyridazine- 3-carboxamide | US11634425, Example 119
Type:
Small organic molecule
Emp. Form.:
C28H19F2N7O3
Mol. Mass.:
539.4924
SMILES:
COc1ccc2nc(c(C(=O)N[C@H]3N=C(c4ccccc4)c4cccc(F)c4NC3=O)n2n1)-c1ccncc1F |r,t:13|
Structure:
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