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Target
Androgen receptor [633-919]
Ligand
BDBM534665
Substrate
n/a
Meas. Tech.
Human Androgen Receptor (hAR) Ligand Binding Domain (LBD) Affinity Assay
Ki
1452±n/a nM
Citation
 Narayanan, R; Miller, DD; Ponnusamy, T; Hwang, D; He, Y Selective androgen receptor degrader (SARD) ligands and methods of use US Patent  US11648234 Publication Date 5/16/2023 
Target
Name:
Androgen receptor [633-919]
Synonyms:
ANDR_HUMAN | AR | Androgen receptor (633-919) | DHTR | NR3C4
Type:
aa 633-919
Mol. Mass.:
33165.80
Organism:
Homo sapiens (Human)
Description:
P10275[633-919]
Residue:
287
Sequence:
KKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
  
Inhibitor
Name:
BDBM534665
Synonyms:
US11230523, Compound ARN-509 | US11648234, Compound ARN-509
Type:
Small organic molecule
Emp. Form.:
C21H15F4N5O2S
Mol. Mass.:
477.435
SMILES:
CC(=O)Nc1ccc(cc1F)N1C(=S)N(C(=O)C11CCC1)c1cnc(C#N)c(c1)C(F)(F)F
Structure:
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