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Target
Orexin receptor type 2
Ligand
BDBM604048
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA) Binding Assay
Ki
794±n/a nM
Citation
 Micheli, F; Bertani, B; Gibson, KR; Di Fabio, R; Raveglia, L; Zanaletti, R; Cremonesi, S; Pozzan, A; Semeraro, T; Tarsi, L; Luker, TJ Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists US Patent  US11660293 Publication Date 5/30/2023 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM604048
Synonyms:
US11660293, Example 152 | US11660293, Example 154
Type:
Small organic molecule
Emp. Form.:
C24H24FN7OS
Mol. Mass.:
477.557
SMILES:
C[C@@H]1C2CC(C2)N(C1CNc1nc2ccc(F)cc2s1)C(=O)c1nc(C)ccc1-n1nccn1 |r,wU:1.0,(-.48,4.78,;-1.81,4.01,;-3.14,4.78,;-4.48,4.01,;-4.48,2.47,;-3.14,3.24,;-3.14,1.7,;-1.81,2.47,;-.48,1.7,;.86,2.47,;2.19,1.7,;2.35,.16,;3.86,-.16,;4.63,-1.49,;6.17,-1.49,;6.94,-.16,;8.48,-.16,;6.17,1.18,;4.63,1.18,;3.6,2.32,;-3.14,.16,;-1.81,-.61,;-4.48,-.61,;-5.81,.16,;-7.14,-.61,;-8.48,.16,;-7.14,-2.15,;-5.81,-2.92,;-4.48,-2.15,;-3.14,-2.92,;-2.98,-4.46,;-1.48,-4.78,;-.71,-3.44,;-1.74,-2.3,)|
Structure:
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