Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349569
Substrate
n/a
Meas. Tech.
Competitive Radioligand Binding Assay
Ki
1.10±n/a nM
Citation
 Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US11691947 Publication Date 7/4/2023 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM349569
Synonyms:
US10207991, Ex. Cpd. No. 87 | US10611728, Example Compound 87 | US11691947, Example 87
Type:
Small organic molecule
Emp. Form.:
C24H33NO4S
Mol. Mass.:
431.588
SMILES:
CC(C)COc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O
Structure:
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