Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Ligand
BDBM608383
Substrate
n/a
Meas. Tech.
Inhibition of Mcl-1 by fluorescence polarization (FP) assay
IC50
9.00±n/a nM
Citation
 Chen, H; Chen, W; Li, C; Li, D; Jing, Y; Tang, G; Zhou, Y; Wang, S; Yang, C Macrocyclic indoles as Mcl-1 inhibitors US Patent  US11691989 Publication Date 7/4/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (171-323)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17540.76
Organism:
Homo sapiens (Human)
Description:
Q07820[171-323]
Residue:
153
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
  
Inhibitor
Name:
BDBM608383
Synonyms:
(Z)-15-chloro-96-fluoro-13,21,25,61- tetramethyl-4-sulfamoyl-11H,21H,61H-10-oxa- 8-thia-4-aza-1(4,1)-indola-2(4,3),6(3,5)- dipyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid | US11691989, Compound 39
Type:
Small organic molecule
Emp. Form.:
C36H37ClFN7O5S2
Mol. Mass.:
766.304
SMILES:
COC(=O)c1c(C)c2c3-c4c(C)n(C)nc4CN(Cc4cc(CSc5cc(OCCCn1c2ccc3Cl)c1ccc(F)cc1c5)n(C)n4)S(N)(=O)=O
Structure:
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