Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM614168
Substrate
n/a
Meas. Tech.
LanthaScreen Eu Kinase Binding Assay
IC50
55±n/a nM
Citation
 Franz, B; Siddiqui-Jain, A; Warner, SL; Basireddy, SR; Padakanti, S; Kumar, N ALK-5 inhibitors and uses thereof US Patent  US11746103 Publication Date 9/5/2023 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM614168
Synonyms:
US11746103, EX-21
Type:
Small organic molecule
Emp. Form.:
C24H25FN8
Mol. Mass.:
444.5073
SMILES:
CN1CCN(CC1)c1ccc(Nc2nccc(Nc3cnnc4c(C)cccc34)n2)c(F)c1
Structure:
Search PDB for entries with ligand similarity: