Reaction Details
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Histone-arginine methyltransferase CARM1
Ligand
BDBM439959
Substrate
n/a
Meas. Tech.
CARM1 Enzyme Assay
IC50
<100±n/a nM
Citation
Chesworth, R; Moradei, OM; Shapiro, G; Jin, L; Babine, RE CARM1 INHIBITORS AND USES THEREOF US Patent US20230279020 Publication Date 9/7/2023 More Info.:
Target
Name:
Histone-arginine methyltransferase CARM1
Synonyms:
CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4)
Type:
Protein
Mol. Mass.:
65855.47
Organism:
Homo sapiens (Human)
Description:
Q86X55
Residue:
608
Sequence:
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIPTNTMHYGS
Inhibitor
Name:
BDBM439959
Synonyms:
US10633389, Example 268-1a | US20230279020, Example 268-1a
Type:
Small organic molecule
Emp. Form.:
C24H29N5O5
Mol. Mass.:
467.5176
SMILES:
CNCC(O)COc1cccc(c1)-c1nc(N[C@@H]2COC(=O)C2)c(C)c(n1)-c1c(C)noc1C |r,wU:17.17,(-10.65,2.34,;-9.32,1.57,;-7.99,2.34,;-6.65,1.57,;-6.65,.03,;-5.32,2.34,;-3.98,1.57,;-2.65,2.34,;-2.65,3.88,;-1.32,4.65,;.02,3.88,;.02,2.34,;-1.32,1.57,;1.35,1.57,;2.68,2.34,;4.02,1.57,;5.35,2.34,;6.68,1.57,;6.85,.04,;8.35,-.28,;9.12,1.05,;10.65,1.21,;8.09,2.2,;4.02,.03,;5.35,-.74,;2.68,-.74,;1.35,.03,;2.68,-2.28,;3.93,-3.19,;5.39,-2.71,;3.45,-4.65,;1.91,-4.65,;1.44,-3.19,;-.03,-2.71,)|
Structure:
