Reaction Details
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GTPase KRas [G12D]
Ligand
BDBM616978
Substrate
n/a
Meas. Tech.
Inhibition of KRas G12D-mediated Phosphorylation of ERK
IC50
5.90±n/a nM
Citation
Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRAS G12D INHIBITORS US Patent US20230279025 Publication Date 9/7/2023 More Info.:
Target
Name:
GTPase KRas [G12D]
Synonyms:
GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21713.12
Organism:
Homo sapiens (Human)
Description:
P01116[G12D]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
Inhibitor
Name:
BDBM616978
Synonyms:
US20230279025, Example 49
Type:
Small organic molecule
Emp. Form.:
C31H32ClFN6O2
Mol. Mass.:
575.076
SMILES:
O[C@@H]1C[C@@H]2CN(CC1N2)c1nc(OCC23CCCN2CCC3)nc2c(F)c(ncc12)-c1cccc2cccc(Cl)c12 |r|
Structure:
