Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM618724
Substrate
n/a
Meas. Tech.
Adenosine Receptor Time-Resolved Fluorescence Resonance Energy Transfer (TRFRET) Binding Assay
Ki
881±n/a nM
Citation
 McCarthy, C; Moulton, B; Walker, ER; McMahon, PS ANTAGONIST COMPOUNDS US Patent  US20230293517 Publication Date 9/21/2023 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM618724
Synonyms:
US20230293517, Example 4.2
Type:
Small organic molecule
Emp. Form.:
C22H22N6O2S2
Mol. Mass.:
466.579
SMILES:
Cc1cc(cc(C)n1)-c1sc(NC(=O)N2CCS(=N)(=O)CC2)nc1-c1cccc(c1)C#N
Structure:
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