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Target
Small ubiquitin-related modifier 1
Ligand
BDBM621226
Substrate
n/a
Meas. Tech.
SAE High Throughput Biochemical Assay Protocol
IC50
320±n/a nM
Citation
 Ouyang, X; Kubota, MD; Tasker, AS; Hong, F; Walton, M; Cee, VJ 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF US Patent  US20230303584 Publication Date 9/28/2023 
Target
Name:
Small ubiquitin-related modifier 1
Synonyms:
SMT3C | SMT3H3 | SUMO1 | SUMO1_HUMAN | Small ubiquitin-related modifier 1 | UBL1
Type:
Protein
Mol. Mass.:
11553.84
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
101
Sequence:
MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV
  
Inhibitor
Name:
BDBM621226
Synonyms:
US20230303584, Compound 325
Type:
Small organic molecule
Emp. Form.:
C23H21ClF3N3OS
Mol. Mass.:
479.946
SMILES:
CCn1nc(c(c1C)-c1ccccc1[C@@H]1CN(Cc2sc(Cl)cc12)C(=O)C=C)C(F)(F)F |wD:14.15,(-5.87,2.15,;-4.34,1.99,;-3.71,.58,;-4.48,-.75,;-3.45,-1.9,;-2.04,-1.27,;-2.2,.26,;-1.06,1.29,;-.71,-2.04,;-.71,-3.58,;.62,-4.35,;1.96,-3.58,;1.96,-2.04,;.62,-1.27,;.62,.27,;-.71,1.04,;-.71,2.58,;.62,3.35,;1.96,2.58,;3.42,3.06,;4.33,1.81,;5.87,1.81,;3.42,.56,;1.96,1.04,;-2.04,3.35,;-2.04,4.89,;-3.38,2.58,;-4.71,3.35,;-3.77,-3.4,;-5.23,-3.88,;-2.63,-4.43,;-4.17,-4.89,)|
Structure:
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