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Target
Casein kinase I isoform delta
Ligand
BDBM625247
Substrate
n/a
Meas. Tech.
CSNK1D Assay
IC50
5.40±n/a nM
Citation
 Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Rauh, U; Bömer, U; Hillig, R; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; McKinney, D ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF US Patent  US20230322767 Publication Date 10/12/2023 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM625247
Synonyms:
2-(4-fluorophenyl)-N-[4-(4-oxo-3-phenyl-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl]acetamide | US20230322767, Example 73
Type:
Small organic molecule
Emp. Form.:
C26H19FN4O2
Mol. Mass.:
438.4531
SMILES:
Fc1ccc(CC(=O)Nc2cc(ccn2)-c2[nH]c3cc[nH]c(=O)c3c2-c2ccccc2)cc1
Structure:
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