Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
Ligand
BDBM626319
Substrate
n/a
Meas. Tech.
HTRF Assay
EC50
160±n/a nM
Citation
Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent US11787775 Publication Date 10/17/2023 More Info.:
Target
Name:
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
Synonyms:
TEAD4 YAP50-100 combined
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Transcriptional enhancer factor TEF-3
Synonyms:
RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3
Type:
PROTEIN
Mol. Mass.:
48333.01
Organism:
Homo sapiens
Description:
ChEMBL_118073
Residue:
434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
Component 2
Name:
Isoform 5 of Transcriptional coactivator [50-100]
Synonyms:
Transcriptional coactivator YAP1 (50-100) | YAP1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5701.47
Organism:
Homo sapiens (Human)
Description:
P46937-5[50-100]
Residue:
51
Sequence:
AGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPE
Inhibitor
Name:
BDBM626319
Synonyms:
2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobenzofuran-5- yl]amino]methyl]prop-2-enamide | US11787775, Compound 33 | US11787775, Compound 4
Type:
Small organic molecule
Emp. Form.:
C22H23N3O2
Mol. Mass.:
361.4369
SMILES:
CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(N)=O)c(C#N)c2CCOc12
Structure:
