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Target
Casein kinase I isoform alpha
Ligand
BDBM415414
Substrate
n/a
Meas. Tech.
CSNK1A1 Inhibitory Activity Asaay 1
IC50
20.3±n/a nM
Citation
 Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Christian, S; Bömer, U; Hillig, null; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; Berger, M; Rupaimoole, R; Lienau, P; Orsi, D; McKinney, D; Brezezinka, K SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF US Patent  US20230339939 Publication Date 10/26/2023 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM415414
Synonyms:
Example 14 (N-{4-[4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide) | US10428063, Example 14 | US20230322767, Example No. 14 WO 2016/120196 | US20230339939, WO 2016/120196, Example 14 | WO 2016/120196, Example 14
Type:
Small organic molecule
Emp. Form.:
C20H19N5O2
Mol. Mass.:
361.3972
SMILES:
CC(=O)Nc1cc(ccn1)-c1[nH]c2CCNC(=O)c2c1Nc1ccccc1
Structure:
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