Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 5
Ligand
BDBM176873
Substrate
n/a
Meas. Tech.
PRMT5/MEP50 Enzyme Assay
IC50
<100±n/a nM
Citation
Duncan, KW; Chesworth, R; Boriack-Sjodin, PA; Munchhof, MJ; Jin, L PRMT5 inhibitors and uses thereof US Patent US9675614 Publication Date 6/13/2017
More Info.:
Target
Name:
Protein arginine N-methyltransferase 5
Synonyms:
Human Flag-PRMT5/6His-MeP50 protein | PRMT5/MeP50
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Protein arginine N-methyltransferase 5
Synonyms:
ANM5_HUMAN | Flag-PRMT5 | HRMT1L5 | IBP72 | JBP1 | PRMT5 | Protein arginine N-methyltransferase 5 (Flag-PRMT5) | SKB1
Type:
Protein
Mol. Mass.:
72548.80
Organism:
Human
Description:
Full-length PRMT5 with FLAG tag fused directly to Ala 2 (MDYKDDDDK removed)
Residue:
636
Sequence:
AAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
Component 2
Name:
Protein arginine N-methyltransferase 5
Synonyms:
6His-MEP50 | ANM5_HUMAN | HRMT1L5 | IBP72 | JBP1 | Methylosome protein 50 (6His-MeP50) | PRMT5 | SKB1
Type:
Protein
Mol. Mass.:
37539.24
Organism:
Human
Description:
Full-length MeP50 with His tag fused directly to Arg 2 of MEP50
Residue:
348
Sequence:
MHHHHHHRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE