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Target
Bisphosphoglycerate mutase
Ligand
BDBM632697
Substrate
n/a
Meas. Tech.
BPGM Synthase Assay
IC50
180±n/a nM
Citation
 Desai, K; Fang, Z; Guertin, K; Hong, V; Jiang, JZ; Lim, S; Munson, M CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE US Patent  US20230348450 Publication Date 11/2/2023 
Target
Name:
Bisphosphoglycerate mutase
Synonyms:
2,3-bisphosphoglycerate mutase, erythrocyte | 2,3-bisphosphoglycerate synthase | 2,3-diphosphoglycerate mutase | 5.4.2.11 | 5.4.2.4 | BPG-dependent PGAM | BPGM | PMGE_HUMAN
Type:
PROTEIN
Mol. Mass.:
30004.85
Organism:
Homo sapiens
Description:
ChEMBL_120651
Residue:
259
Sequence:
MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQAKK
  
Inhibitor
Name:
BDBM632697
Synonyms:
US20230348450, Example 78
Type:
Small organic molecule
Emp. Form.:
C22H15N5O3S
Mol. Mass.:
429.451
SMILES:
Cc1nc(COc2ncccn2)sc1-c1cccc(n1)-c1ccc(C(O)=O)c(c1)C#N
Structure:
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