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Target
Aurora kinase B
Ligand
BDBM636078
Substrate
n/a
Meas. Tech.
Aurora B Kinase Biochemical Assay
IC50
106±n/a nM
Citation
 NDUBAKU, C; MOORE, JT; GIBBONS, PA; CHANG, JH; ROMERO, FA; DU, X; KAWAI, H; CIBLAT, S; WANG, H; ALBERT, V; CONSTANTINEAU-FORGET, L; SILVA, H; POLAT, DE; NAYYAR, A; SHORE, DG; WU, K; TAN, J POLO LIKE KINASE 4 INHIBITORS US Patent  US20230365537 Publication Date 11/16/2023 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM636078
Synonyms:
(1R,2S)-2-{3-[5-fluoro-2-methoxy-4-(morpholine-4-carbonyl)anilino]-1H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one | US20230365537, Example 207
Type:
Small organic molecule
Emp. Form.:
C30H28FN5O5
Mol. Mass.:
557.5722
SMILES:
COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(Nc5cc(F)c(cc5OC)C(=O)N5CCOCC5)n[nH]c4c3)c2c1
Structure:
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