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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50603929
Substrate
n/a
Meas. Tech.
MAOA and MAOB In Vitro Activity Assay
IC50
32880±1240 nM
Citation
 Liu, H; Li, J; Zhu, W; Zhou, Y; Wang, J; Su, M; Wang, S; Xu, W; Li, C; Kan, W; Jiang, H; Chen, K Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof US Patent  US11873292 Publication Date 1/16/2024 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Human
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50603929
Synonyms:
CHEMBL5201504 | US11873292, Compound A45
Type:
Small organic molecule
Emp. Form.:
C24H29N3O
Mol. Mass.:
375.5066
SMILES:
O=C(N1CCc2cc(ccc12)C1CC1NCC1CCNCC1)c1ccccc1
Structure:
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