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Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM647662
Substrate
n/a
Meas. Tech.
RIPK1-ADP-Glo Enzymatic Assay
EC50
696±n/a nM
Citation
 Chen, JL; Chen, Y; DiMauro, EF; Liu, M; Methot, JL; Musacchio, AJ; Palani, A; Pio, B; Duque, LR; Siliphaivanh, P; Vara, BA RIPK1 INHIBITORS AND METHODS OF USE US Patent  US20240025912 Publication Date 1/25/2024 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM647662
Synonyms:
(S)-2-(bicyclo[2.1.1]hexan-1-yl)-5- (pyrazin-2-yl)-2,5,6,7-tetrahydro-3H- pyrrolo[2,1-c][1,2,4]triazol-3-one | US20240025912, Compound 1-61
Type:
Small organic molecule
Emp. Form.:
C15H17N5O
Mol. Mass.:
283.3284
SMILES:
O=c1n2[C@@H](CCc2nn1C12CC(C1)CC2)c1cnccn1 |r,wU:3.18,(.66,.94,;.34,-.57,;-1.06,-1.19,;-2.57,-.87,;-3.34,-2.2,;-2.31,-3.35,;-.9,-2.72,;.6,-3.04,;1.37,-1.71,;2.9,-1.55,;3.64,-.19,;5.15,-.47,;4.44,-1.55,;5.36,-2,;3.97,-2.66,;-3.2,.54,;-4.73,.7,;-5.36,2.1,;-4.45,3.35,;-2.92,3.19,;-2.29,1.78,)|
Structure:
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