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Target
P2X purinoceptor 3
Ligand
BDBM648789
Substrate
n/a
Meas. Tech.
Evaluation of In Vitro Biological Activity
IC50
1.80±n/a nM
Citation
 LOU, J; CHEN, Y; LIU, J; ZHANG, Y; GUO, X; LIU, L; QIAN, L; WANG, C HETEROCYCLIC COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF US Patent  US20240034729 Publication Date 2/1/2024 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:
Protein
Mol. Mass.:
44292.02
Organism:
Homo sapiens (Human)
Description:
P56373
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
  
Inhibitor
Name:
BDBM648789
Synonyms:
US20240034729, Compound 181
Type:
Small organic molecule
Emp. Form.:
C20H19Cl2FN4O5S
Mol. Mass.:
517.358
SMILES:
COC(=O)N1CCO[C@@H](Cc2c(nc3cc(Cl)ccn23)-c2cc(F)c(cc2Cl)S(N)(=O)=O)C1 |r|
Structure:
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