Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [364-436]
Ligand
BDBM179460
Substrate
n/a
Meas. Tech.
FP Competitive Binding Assay (BRD-1F)
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
<10.00±n/a nM
IC50
142±31 nM
Comments
extracted
Citation
Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017
More Info.:
Target
Name:
Bromodomain-containing protein 2 [364-436]
Synonyms:
BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)(BD2) | Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | KIAA9001 | RING3
Type:
Protein
Mol. Mass.:
8615.14
Organism:
Human
Description:
BD2 (364-436 aa) of P25440
Residue:
73
Sequence:
KHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVV
Inhibitor
Name:
BDBM179460
Synonyms:
US9675697, Cpd. No. 17
Type:
Small organic molecule
Emp. Form.:
C25H20N4O2
Mol. Mass.:
408.4519
SMILES:
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c[nH]c4ccccc34)c21 |(-1.88,2.57,;-2.65,1.24,;-1.88,-.09,;-.34,-.09,;.43,-1.43,;-.34,-2.76,;-1.88,-2.76,;-2.65,-1.43,;-4.19,-1.43,;-5.1,-2.67,;-4.7,-4.16,;-6.56,-2.2,;-6.56,-.66,;-5.1,-.18,;-4.7,1.31,;.69,-3.9,;2.09,-3.28,;3.5,-3.9,;4.75,-3,;4.59,-1.47,;3.18,-.84,;2.78,.65,;1.53,1.55,;2.01,3.02,;3.55,3.02,;4.58,4.16,;6.09,3.84,;6.56,2.38,;5.53,1.23,;4.03,1.55,;1.93,-1.75,)|