Reaction Details Report a problem with these data
Target
enzyme inhibitor1 15-pgdh
Ligand
BDBM650826
Substrate
n/a
Meas. Tech.
In vitro Assay (1 nM)
IC50
0.720±n/a nM
Citation
 Markowitz, S; Antczak, M; Ready, J; Zhang, Y COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY US Patent  US20240043440 Publication Date 2/8/2024 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM650826
Synonyms:
US20240043440, Example 39A
Type:
Small organic molecule
Emp. Form.:
C20H22N6OS2
Mol. Mass.:
426.558
SMILES:
CCCC[S@@](=O)c1sc2nc(cc(-c3cnc(C)n3C)c2c1N)-c1cncnc1 |r|
Structure:
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