Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50567991
Substrate
n/a
Meas. Tech.
DHODH Kinetic Analysis
IC50
>100000±n/a nM
Citation
 Phillips, M; Palmer, M; Charman, SA; Watts, KS; Gerasyuto, AI; Krilov, G Anti-malarial agents US Patent  US11903936 Publication Date 2/20/2024 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
80875.72
Organism:
Dog
Description:
A0A8I3N262
Residue:
740
Sequence:
MAWRQLKKRVQDAVVILGGGGLLFTSYLTAMGDEHFYAEHLMPAMQRLLDPESAHRLAVRVTSLGLLPRATFQESDMLEVRVLGHRFRNPIGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLLARQEKQARLTEEGLPLGINLGKNKTSVDAAADYTEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRHLLAKVLQERDALQGAHKPAVLVKIAPDLTAQDKEDIASVVKELGIDGLIITNTTVSRPASLQGALRSEIGGLSGKPLRDLSTQTIREMYALTQGGVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTYRGPPVVGMIKRELEALLKEQGFTRITDAIGADHRRALGAVIALLLWGQLFAEDTGSEATNNTEVSLPKPPVIENGYVEHMIRYQCKPFYKLHTEGDGVYTLNSEKHWTNKAVGEKLPECEAVCGKPKNPVDQVQRIMGGSVDAKGSFPWQAKMVSHHNLTSGATLINEQWLLTTAKNLFLGHKDDAKANDIAPTLKLYVGKNQLVEVEKVVLHPDYSKVDIGLIKLKQKVPIDERVMPICLPSKDYAEVGRIGYVSGWGRNSNFNFTELLKYVMLPVADQDKCVQHYEGSTVPEKKSPKSPVGVQPILNEHTFCAGMSKFQEDTCYGDAGSAFAVHDQDEDTWYAAGILSFDKSCTVAEYGVYVKVPSVLAWVQETIAGN
  
Inhibitor
Name:
BDBM50567991
Synonyms:
CHEMBL4848632 | US11903936, Compound 2
Type:
Small organic molecule
Emp. Form.:
C19H19F3N6O
Mol. Mass.:
404.389
SMILES:
CC(NC(=O)c1[nH]cc(c1C)C1(CC1)c1ccc(nc1)C(F)(F)F)c1nc[nH]n1
Structure:
Search PDB for entries with ligand similarity: