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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM627288
Substrate
n/a
Meas. Tech.
DGAT2 Enzymatic Activity Assay
IC50
1.000±n/a nM
Citation
 Lim, Y; Bao, J; Cruz, FA; Ding, F; Hugelshofer, CL; Mak, VW; Roane, JP; Sanzone, JR; Shockley, SE; Yen, R NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS US Patent  US20240059700 Publication Date 2/22/2024 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM627288
Synonyms:
3-(5-(difluoromethoxy)-2- fluorophenyl)-1-isopropyl-N- (3-methyl-1,1- dioxidothietan-3-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide | US11787810, Example 113 | US20240059700, Example 113
Type:
Small organic molecule
Emp. Form.:
C21H21F3N4O4S
Mol. Mass.:
482.476
SMILES:
CC(C)n1nc(-c2cc(OC(F)F)ccc2F)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1
Structure:
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