Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM10866
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
Ki
63±n/a nM
Citation
Nishimori, I; Minakuchi, T; Morimoto, K; Sano, S; Onishi, S; Takeuchi, H; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. J Med Chem 49:2117-26 (2006) [PubMed] Article
More Info.:
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Inhibitor
Name:
BDBM10866
Synonyms:
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide | CHEMBL418 | aromatic/heteroaromatic sulfonamide 11
Type:
Small organic molecule
Emp. Form.:
C7H8F3N3O4S2
Mol. Mass.:
319.281
SMILES:
Nc1cc(c(cc1S(N)(=O)=O)S(N)(=O)=O)C(F)(F)F