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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM340795
Substrate
n/a
Meas. Tech.
IDO Kynurenine Assay
IC50
1310±n/a nM
Citation
 Markwalder, JA; Seitz, SP; Balog, JA; Huang, A; Mandal, SK; Williams, DK; Hart, AC; Inghrim, J IDO inhibitors US Patent  US9765018 Publication Date 9/19/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM340795
Synonyms:
4'-(2-(tert-butyl) phenoxy)-3'-(3-(2,4- dichlorophenyl)ureido)-4- methoxy-[1,1'-biphenyl]- 3-carboxylic acid | US9765018, Example 103
Type:
Small organic molecule
Emp. Form.:
C31H28Cl2N2O5
Mol. Mass.:
579.47
SMILES:
COc1ccc(cc1C(O)=O)-c1ccc(Oc2ccccc2C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2Cl)c1
Structure:
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