Reaction Details Report a problem with these data
Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM341523
Substrate
n/a
Meas. Tech.
Biochemical In Vitro Assay
IC50
2.00±n/a nM
Citation
Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017
More Info.:
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Human
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
Inhibitor
Name:
BDBM341523
Synonyms:
1-(5-(5-chloro-3-fluoropyridin-2-yl)-2-methyl-7,8-dihydro[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-chloro-6-morpholinopyridin-3-yl)oxy)ethanone | US9765092, Example 1.33.1
Type:
Small organic molecule
Emp. Form.:
C24H22Cl2FN7O3S
Mol. Mass.:
578.446
SMILES:
Cc1nn2c3C(N(CCc3nc2s1)C(=O)COc1ccc(nc1Cl)N1CCOCC1)c1ncc(Cl)cc1F