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Target
Non-receptor tyrosine-protein kinase TYK2 [871-1187]
Ligand
BDBM349184
Substrate
n/a
Meas. Tech.
TYK2 Inhibition Assay
IC50
300±n/a nM
Citation
 Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent  US10206907 Publication Date 2/19/2019 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [871-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 | Non-receptor tyrosine-protein kinase TYK2 (871-1187) | TYK2 | TYK2 (aa 871-1187) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36255.07
Organism:
Homo sapiens (Human)
Description:
P29597[871-1187]
Residue:
317
Sequence:
PHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM349184
Synonyms:
Cyclopropanecarboxylic acid (5-{4-[2-oxo-2-(4- trifluoromethyl-piperidin-1- yl)-ethyl]-phenyl}- [1,2,4]triazolo[1,5-a]pyridin-2 yl)-amide | US10206907, Compound 319
Type:
Small organic molecule
Emp. Form.:
C24H24F3N5O2
Mol. Mass.:
471.4749
SMILES:
FC(F)(F)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Structure:
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