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Target
Proto-oncogene tyrosine-protein kinase Src [145-252]
Ligand
BDBM14687
Substrate
Peptide Substrate
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
4400000±n/a nM
Citation
Lange, G; Lesuisse, D; Deprez, P; Schoot, B; Loenze, P; Benard, D; Marquette, JP; Broto, P; Sarubbi, E; Mandine, E Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J Med Chem 46:5184-95 (2003) [PubMed] Article
More Info.:
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [145-252]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src | Proto-oncogene tyrosine-protein kinase Src (aa 145-252) | SRC | SRC1 | SRC_HUMAN | c-Src pp60c-src | p60-Src
Type:
SH2 Domain
Mol. Mass.:
12362.36
Organism:
Human
Description:
Src-SH2 proteins (amino acid residues 145-252) were chemically biotinylated using a 10-fold molar excess of D-biotin-N-hydroxy-succinimidester and purified by gel filtration yielding conjugates with an average ratio of two biotin moieties per protein molecule.
Residue:
108
Sequence:
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK
Inhibitor
Name:
BDBM14687
Synonyms:
CHEMBL284362 | Fragment 17 | ISO24 | [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID | [(4-ethylphenyl)carbamoyl]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C9H12NO4P
Mol. Mass.:
229.1696
SMILES:
CCc1ccc(NC(=O)P(O)(O)=O)cc1
Substrate
Name:
Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1600.79
Organism:
n/a
Description:
Peptide EPQpYEEIPIYL (middle-T antigen) was monoiodinated on tyrosine.
Residue:
13
Sequence:
IEPQPYEEIPIYL