Reaction Details
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Target
Proto-oncogene tyrosine-protein kinase Src [145-252]
Ligand
BDBM14698
Substrate
Peptide Substrate
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
2200±n/a nM
Citation
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More Info.:
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [145-252]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src | Proto-oncogene tyrosine-protein kinase Src (aa 145-252) | SRC | SRC1 | SRC_HUMAN | c-Src pp60c-src | p60-Src
Type:
SH2 Domain
Mol. Mass.:
12362.36
Organism:
Homo sapiens (Human)
Description:
Src-SH2 proteins (amino acid residues 145-252) were chemically biotinylated using a 10-fold molar excess of D-biotin-N-hydroxy-succinimidester and purified by gel filtration yielding conjugates with an average ratio of two biotin moieties per protein molecule.
Residue:
108
Sequence:
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK
Inhibitor
Name:
BDBM14698
Synonyms:
2-{4-[(1Z)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]carbamoyl}eth-1-en-1-yl]-2-formylphenyl}acetic acid | Inhibitor 10 | RU82129 | {4-[(1Z)-2-(acetylamino)-3-{[(3S)-1-(biphenyl-4-ylmethyl)-2-oxoazepan-3-yl]amino}-3-oxoprop-1-en-1-yl]-2-formylphenyl}acetic acid
Type:
Small organic molecule
Emp. Form.:
C33H33N3O6
Mol. Mass.:
567.6316
SMILES:
CC(=O)N\C(=C/c1ccc(CC(O)=O)c(C=O)c1)C(=O)N[C@H]1CCCCN(Cc2ccc(cc2)-c2ccccc2)C1=O |r|
Substrate
Name:
Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1600.79
Organism:
n/a
Description:
Peptide EPQpYEEIPIYL (middle-T antigen) was monoiodinated on tyrosine.
Residue:
13
Sequence:
IEPQPYEEIPIYL