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Target
Aurora kinase A
Ligand
BDBM25521
Substrate
PKA-specific peptide substrate
Meas. Tech.
Plk in Vitro Assay
IC50
6800±n/a nM
Citation
 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg Med Chem Lett 18:5648-52 (2008) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM25521
Synonyms:
2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]phenyl}acetamide
Type:
Small organic molecule
Emp. Form.:
C29H26ClN5O
Mol. Mass.:
496.003
SMILES:
C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
PKA-specific peptide substrate
Synonyms:
PKAtide
Type:
Peptide
Mol. Mass.:
1019.14
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
GRTGRRNSI